Sex and sex steroids impact influenza pathogenesis across the life course
Identifieur interne : 000158 ( Main/Exploration ); précédent : 000157; suivant : 000159Sex and sex steroids impact influenza pathogenesis across the life course
Auteurs : Landon G. Vom Steeg ; Sabra L. KleinSource :
- Seminars in immunopathology [ 1863-2297 ] ; 2018.
Abstract
Males and females differ in the outcome of influenza A virus (IAV) infections, which depends significantly on age. During a typical seasonal influenza epidemic, young children (<5 years of age) and aged adults (65+ years of age) are at greatest risk for severe disease, and among these age groups, males tend to suffer a worse outcome from IAV infection than females. Following infection with either pandemic or outbreak strains of IAVs, females of reproductive ages (i.e., 15–49 years of age) experience a worse outcome than their male counterparts. Among females of reproductive ages, pregnancy is one factor linked to an increased risk of severe outcome of influenza, although it is not the sole factor explaining the femalepreponderance of severe disease. Small animal models of influenza virus infection illustrate that inflammatory immune responses and repair of damaged tissue following IAV infection also differ between the sexes and impact the outcome of infection. There also is growing evidence that sex steroid hormones, including estrogens, progesterone, and testosterone, directly impact immune responses during IAV infection to alter outcomes. Greater consideration of the combined effects of sex and age as biological variables in epidemiological, clinical, and animal studies of influenza pathogenesis is needed.
Url:
DOI: 10.1007/s00281-018-0718-5
PubMed: 30298431
PubMed Central: 6370518
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000822
- to stream Pmc, to step Curation: 000822
- to stream Pmc, to step Checkpoint: 000112
- to stream Ncbi, to step Merge: 000F23
- to stream Ncbi, to step Curation: 000F23
- to stream Ncbi, to step Checkpoint: 000F23
- to stream Main, to step Merge: 000158
- to stream Main, to step Curation: 000158
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sex and sex steroids impact influenza pathogenesis across the life course</title><author><name sortKey="Vom Steeg, Landon G" sort="Vom Steeg, Landon G" uniqKey="Vom Steeg L" first="Landon G." last="Vom Steeg">Landon G. Vom Steeg</name></author><author><name sortKey="Klein, Sabra L" sort="Klein, Sabra L" uniqKey="Klein S" first="Sabra L." last="Klein">Sabra L. Klein</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30298431</idno><idno type="pmc">6370518</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370518</idno><idno type="RBID">PMC:6370518</idno><idno type="doi">10.1007/s00281-018-0718-5</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000822</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000822</idno><idno type="wicri:Area/Pmc/Curation">000822</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000822</idno><idno type="wicri:Area/Pmc/Checkpoint">000112</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000112</idno><idno type="wicri:Area/Ncbi/Merge">000F23</idno><idno type="wicri:Area/Ncbi/Curation">000F23</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F23</idno><idno type="wicri:doubleKey">1863-2297:2018:Vom Steeg L:sex:and:sex</idno><idno type="wicri:Area/Main/Merge">000158</idno><idno type="wicri:Area/Main/Curation">000158</idno><idno type="wicri:Area/Main/Exploration">000158</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sex and sex steroids impact influenza pathogenesis across the life course</title><author><name sortKey="Vom Steeg, Landon G" sort="Vom Steeg, Landon G" uniqKey="Vom Steeg L" first="Landon G." last="Vom Steeg">Landon G. Vom Steeg</name></author><author><name sortKey="Klein, Sabra L" sort="Klein, Sabra L" uniqKey="Klein S" first="Sabra L." last="Klein">Sabra L. Klein</name></author></analytic><series><title level="j">Seminars in immunopathology</title><idno type="ISSN">1863-2297</idno><idno type="eISSN">1863-2300</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Males and females differ in the outcome of influenza A virus (IAV) infections, which depends significantly on age. During a typical seasonal influenza epidemic, young children (<5 years of age) and aged adults (65+ years of age) are at greatest risk for severe disease, and among these age groups, males tend to suffer a worse outcome from IAV infection than females. Following infection with either pandemic or outbreak strains of IAVs, females of reproductive ages (i.e., 15–49 years of age) experience a worse outcome than their male counterparts. Among females of reproductive ages, pregnancy is one factor linked to an increased risk of severe outcome of influenza, although it is not the sole factor explaining the femalepreponderance of severe disease. Small animal models of influenza virus infection illustrate that inflammatory immune responses and repair of damaged tissue following IAV infection also differ between the sexes and impact the outcome of infection. There also is growing evidence that sex steroid hormones, including estrogens, progesterone, and testosterone, directly impact immune responses during IAV infection to alter outcomes. Greater consideration of the combined effects of sex and age as biological variables in epidemiological, clinical, and animal studies of influenza pathogenesis is needed.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Klein, Sabra L" sort="Klein, Sabra L" uniqKey="Klein S" first="Sabra L." last="Klein">Sabra L. Klein</name><name sortKey="Vom Steeg, Landon G" sort="Vom Steeg, Landon G" uniqKey="Vom Steeg L" first="Landon G." last="Vom Steeg">Landon G. Vom Steeg</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000158 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000158 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6370518
|texte= Sex and sex steroids impact influenza pathogenesis across the life course
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30298431" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |